Redmayne's film The Danish Girl, about the transgender artist Lili Elbe, will feature at the star-studded festival which does not have a jury and is non-competitive.
Toronto will also host the gala premiere for Freeheld, in which Moore and Ellen Page play domestic partners.
Redmayne and Moore won the top trophies at the Academy Awards for their respective roles in The Theory Of Everything and Still Alice.
But it is Jake Gyllenhaal and Naomi Watts' film Demolition which will open the event on 10 September.
The drama, from Wild director Jean-Marc Vallee, is about an investment banker who struggles after losing his wife.
The festival will also see world premieres for Ridley Scott's space epic The Martian, starring Matt Damon and Jessica Chastain, and Stephen Frears' Lance Armstrong biopic The Program, starring Ben Foster.
source: sky news
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